euL1db - The European database of L1-HS retrotransposon insertions in humans

Description
In this study authors applied a high-throughput method to identify numerous L1, Alu and SVA germline mutations, as well as putative somatic L1 insertions, in the hippocampus and caudate nucleus of three individuals. Surprisingly, authors also found somatic Alu insertions and SVA insertions. There results demonstrate that retrotransposons mobilize to protein-coding genes differentially expressed and active in the brain. Thus, somatic genome mosaicism driven by retrotransposition may reshape the genetic circuitry that underpins normal and abnormal neurobiological processes.

Mapped assembly	Original assembly	Browse by SRIP	Browse by MRIP
hg19_NCBI37	hg19_NCBI37	SRIP	MRIP

Sample ID	Sample name	Relationship	Clinical	Anatomopathology	Tissue	Sub Tissue	WGA	Size
610	DonorAH	Solo	Healthy	Normal	Brain	Hippocampus	no	cell-pool
611	DonorAR1	Solo	Caudate_Rep1	Normal	Brain	Caudate	no	cell-pool
612	DonorAR2	Solo	Caudate_Rep2	Normal	Brain	Caudate	no	cell-pool
613	DonorBH	Solo	Healthy	Normal	Brain	Hippocampus	no	cell-pool
614	DonorBC	Solo	Healthy	Normal	Brain	Caudate	no	cell-pool
615	DonorCH	Solo	Healthy	Normal	Brain	Hippocampus	no	cell-pool
616	DonorCC	Solo	Healthy	Normal	Brain	Caudate	no	cell-pool
617	Pooled_Blood	Multiple	Healthy	Normal	Blood	Leukocytes	no	cell-pool

Individual Name	Gender	Population	Clinical	Disease	Relationship	Father
DonorA	Male	CEU	Healthy	unknown	Unrelated	.
DonorB	Male	CEU	Healthy	unknown	Unrelated	.
DonorC	Female	CEU	Healthy	unknown	Unrelated	.
Pooled_Blood_Baillie2011	Male	CEU	Healthy	unknown	Unrelated	.

euL1db The European database of L1-HS retrotransposon insertions in humans

euL1db

The European database of L1-HS retrotransposon insertions in humans